研究業績・総説等

2011
『多田富雄の世界』
 古澤修一共著

『イラストでみる獣医免疫学』—免疫疾患の仕組みから治療まで—  古澤修一 監訳、堀内浩幸分担

Nakano, M., Arisawa, K., Yokoyama, S., Nishimoto, M., Yamashita, Y., Sakashita, M., Fukushima, Y., Ezaki, R., Furusawa, S., Matsuda, H. and Horiuchi, H. (2011) Characteristics of novel chicken embryonic stem cells established using chicken leukemia inhibitory factor. J. Poult. Sci. 48(1): 64-72.

堀内浩幸,中野幹治 (2011)鶏の遺伝子組換え技術のこれまでとこれから〜遺伝子組換え鶏の作出方法1〜,鶏の研究, 86巻2号,24-26.

堀内浩幸,中野幹治 (2011)鶏の遺伝子組換え技術のこれまでとこれから,鶏の研究〜遺伝子組換え鶏の作出方法2〜, 86巻4号,23-25.

堀内浩幸,中野幹治 (2011)鶏の遺伝子組換え技術のこれまでとこれから〜遺伝子組換え鶏の作出方法3〜,鶏の研究, 86巻6号,23-25.

2010

Elazab, M. F., Fukushima, Y., Horiuchi, H., Matsuda, H. and Furusawa, S. (2010) Induction of immune suppression in the chick by an optimal dose of an immunizing antigen in presence of its specific maternal antibody. J. Vet. Med Sci. 72(3): 257-262.

堀内浩幸,中野幹治 (2010)鶏の遺伝子組換え技術のこれまでとこれから,鶏の研究〜育種と遺伝子組換え1〜, 85巻6号,18-20.

堀内浩幸,中野幹治 (2010)鶏の遺伝子組換え技術のこれまでとこれから〜育種と遺伝子組換え2〜,,鶏の研究, 85巻8号,18-20.

堀内浩幸,中野幹治 (2010)鶏の遺伝子組換え技術のこれまでとこれから〜遺伝子組換えという技術の基礎1〜,鶏の研究, 85巻10号,20-22.

堀内浩幸,中野幹治 (2010)鶏の遺伝子組換え技術のこれまでとこれから〜遺伝子組換えという技術の基礎2〜,鶏の研究, 85巻12号,24-26.

堀内浩幸,有澤謙二郎 (2010)ニワトリの万能細胞“ES細胞”とその遺伝子組換え,化学と生物,Vol.48, 237-242.

Nakano, M., Fukushima, Y., Arisawa, K., Nishimoto, M., Ezaki, R., Furusawa, S., Matsuda, H. and Horiuchi, H. (2010) Establishment of novel chicken embryonic stem cells capable of differentiating into germ cells. Dev. Biol. 344: 133.

Fukushima, Y., Sato, M., Matsuda, H.,Furusawa, S. and Horiuchi, H. (2010) Construction of an insertion vector for gene targeting of chicken lens-specific gene. J. Poul. Sci., 47(2):144-148.

堀内浩幸,江崎 僚 (2010)アレルギーフリーの卵開発は可能か,養鶏の友, Vol.575, 29-31.

Nakamura, R., Nakamura, R., Nakano, M., Arisawa, K., Ezaki, R., Horiuchi, H. and Teshima, R. (2010) Allergenicity study of EGFP-transgenic chicken meat by serological and 2D-DIGE analysis. Food Chem. Toxicol., 48(5), 1302-1310.


2009

Elazab, M. F., Fukushima, Y., Horiuchi, H., Matsuda, H. and Furusawa, S. (2009) Prolonged suppression of chick humoral immune response by antigen specific maternal antibody. J. Vet. Med Sci. 71(4): 417-424.

大原健一,景山哲史,桑田知宣,海野徹也,古澤修一,吉浦康寿,2009,リアルタイムPCRを用いたアユ冷水病魚におけるFlavobacterium Psychrophilumの定量性の検討.日本水産学会誌,75(2): 259-260.


Iwamoto, S., Nishimichi, N., Tateishi , Y., Sato, Y., Horiuchi, H.,
Furusawa, S., Sawamura, T. and Matsuda, H. (2009)
Generation and characterization of chicken monoclonal antibodies
against human LOX-1. mAbs., 1(4):357-363.

Kushima, K.., Sakuma, S., Furusawa, S. and Fujiwara, M. (2009) Prenatal administration of indomethacain modulates Th2 cytokines in juvenile rats. Toxicol. Lett., 185(1):32-37

Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T. (2009) Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects. Clin Chem., 55(2):285-294.

Nishimichi, N., Higashikawa, F., Kinoh, HH., Tateishi, Y., Matsuda, H. and Yokosaki, Y. (2009) Polymeric osteopontin employs integrin alpha9 beta1 as a receptor and attracts neutrophils by presenting a de novo binding site. J. Biol. Chem., 284(22):14769-76.

2008

Sato, Y., Nishimichi, N., Nakano, A., Takikawa, K., Inoue, N., Matsuda, H., Sawamura, T. (2008) Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB. Athrosclerosis (in press)

Tateishi, Y., Nishimichi, N., Horiuchi, H., Furusawa, S. and Matsuda, H. (2007) Construction of Chicken-Mouse Chimeric Antibody and Immunogenicity in Mice. J. Vet. Med. Sci. (in press)

2007

Miyamoto, K., Shimamoto, T., Aosasa, M., Kimura, S., Nakamura, N., Okubo, Y., Yokoyama, T., Horiuchi, H., Furusawa, S. and Matsuda, H. (2007) Development of recombinant chicken IgY from single chain fragment of variable region for diagnosis of BSE. Biologicals 35:31-34.

Miyoshi, M., Horiuchi, H., Fukushima, Y., Matsuda, H. and Furusawa, S. (2007) Cloning of the chicken interleukin-13 receptor alpha2 gene and production of a specific monoclonal antibody. Dev. Comp. Immunol. 31:394-406.

Miyamoto, K., Kimura, S., Nakamura, N., Yokoyama, T., Horiuchi, H.,Furusawa, S. and Matsuda, H. (2007) Chicken antibody against a restrictive epitope of prion protein distinguishes normal and abnormal prion proteins. Biologicals.

2006

堀内浩幸, 山下裕輔, 西田憲正, 古澤修一, 松田治男. (2006) ニワトリにおける抗体エンジニアリングとトランスジェニックテクノロジー, FOODS & FOOD INGREDIENTS JOURNAL OF JAPAN, 211(11):948-955.

Horiuchi, H., Furusawa, S. and Matsuda, H. (2006) Maintenance of chicken emboryonic stem cells in vitro. Methods Mol. Biol., 329:17-34.

Nishibori, N., Horiuchi, H., Furusawa, S. and Matsuda, H. (2006) Humanization of chicken monoclonal antibody using phage-display system. Mol. Immunol., 43(6):634-642.

Nishimichi, N., Kawashima, T., Hojyo, S., Horiuchi, H., Furusawa, S. and Matsuda, H. (2006) Characterization and expression analysis of a chicken Interleukin-6 recepter alpha. Dev. Comp. Immunol., 30(4):419-429.

Yamashita, Y., Tategaki, A. , Ogawa, M., HORIUCHI, H., Nishida, K. , Akita, S., Matsuda, H. and Furusawa, S. (2006) Effect of novel monoclonal antibodies on LIF-induced signaling in chicken blastodermal cells. Dev. Comp. Immunol., 30(5):513-522.

Muramoto, Y., Ozaki, H., Takeda, A., Park, C-H., Sunden, Y., Umeura, T., Kawaoka, Y., Matsuda, H. and Kida, H. (2006) Highly pathogenic H5N1 influenza virus causes coagulopathy in chickens. Microbiol. Immunol., 50:71-81.

Asakawa, H., Sasabe, M., Miyazaki, R., Matsuda, H., Fukai, F., Hanada, K., Hirano, H. and Takasaki, S. (2006) The analysis of N-glycolylneuraminic acid (NeuGc) of hepatoma tissue and K562 cell ferritins using HPLC and mass spectrometry. Proc. Jpn. Asad. Ser8. 82:181-187.

2005

Kawashima, T., Hojyo, S., Nishimichi, n., Sato, M., Aosasa, M., Horiuchi, H., Furusawa S. and Matsuda, H. (2005) Characterization and expression analysis of the chicken interleukin-11 receptor alpha chain. Dev. Comp. Immunol., 29:349-359.
Nishimichi, N., Aosasa, M., Kawashima, T., Horiuchi, H., Furusawa, S. and Matsuda, H. (2005) Generation of mouse monoclonal antibody against chicken interleukin-6. Hybridoma and Hybridomics, 24:115-117.

Sato, M., Kawashima, T., Aosasa, M., Horiuchi, H., Furusawa, S. and Matsuda, H. (2005) Excision of foreign product with cathepsin D in chicken hepatoma cell line. Biochem. Biophys. Res. Commun., 330:533-539.

Matsubayashi, M., Kimata, I., Iseki, M., Lillehoj, H. S., Matsuda, H., Nakanishi, T., Tani, H., Sasai, K. and Baba, E. (2005) Cross-reactivities with Cryptosporidium spp. by chicken monoclonal antibodies that recognize avian Eimeria spp. Vet. Parasitol., 128:47-57.

Shimamoto, T., Nishibori, N., Aosasa, M., Horiuchi, H., Furusawa, S. and Matsuda, H. (2005) Stable production of recombinant chicken antibody in CHO-K1 cell line. Biologicals, 33:169-174.

松田治男 (2005)ニワトリの抗体作成とその利便性,p. 37-43. 組織細胞化学2005 (日本組織細胞化学会編),学際企画,東京


2004
Kushima, K., Yoshida, K., Fujita, M., Shigeta, A., Horiuchi, H., Matsuda, H. and Furusaawa, S. (2004) Chicken peripheral blood CD3&CD4-CD8- cells are regulated by endocrine and immune system. J. Vet. Med. Sci., 66: 142-148.

Horiuchi, H., Tanaka, K., Shigeta, A., Yoshida, K., Kushima, K., Ohta, S., Furusawa, S. and Matsuda, H. (2004) A monoclonal antibody against chicken peripheral blood thrombocytes react with the cells of thrombocyte lineage. J. Vet. Med. Sci., 66:243-250.

Sayed, A., Horiuchi, H., Furusawa, S. and Matsuda, H. (2004) Molecular study on chicken tumor necrosis factor receptor-associated factor 5. Vet. Immunol. Immunopathol. 98:31-41.

Constantinoiu, C. C., Lillehoj, H. S., Matsubayashi, M., Tani, H., Matsuda, H., Sasai, K. and Baba, E. (2004) Characterization of stage-specific and cross-reactive antigens from Eimeria acervulina by chicken monoclonal antibodies. J. Vet. Med. Sci., 66, 403-408.

Sayed, A., Horiuchi, H., Furuswa, F. and Matsuda, H. (2004) Molecular cloning and characterization of chicken tumor necrosis factor (TNF)-superfamily ligands, CD30 Ligand and TNF-related apoptosis inducing ligand (TRAIL). J. Vet. Med. Sci., 66:643-650.

Horiuchi, H., Tategagi, A., yamashita, Y., Hisamatsu, H., Ogawa, M., Noguchi, T., Aosasa, M., Kawashima, T., Akita, S., Nishimichi, N., Mitsui, N., Furusawa, S. and Matsuda, H. (2004) Chicken leukemia inhibitory factor maintains chicken embryonic stem cells in the undifferented state. J. Biol. Chem., 279:24514-24520.

Nakamura, N., Shuyama, A., Shimokawa, M., Miyamoto, K., Hojyo, S., Horiuchi, H., Furusawa, S. and Matsuda, H. (2004) Establishment of a chicken monoclonal antibody panel against mammalian prion protein. J. Vet. Med. Sci., 66:807-814.

Kikuchi, Y., Kakeya, T., Sakai, A., Takatori, K., Nakamura, N., Matsuda, H., Yamazaki, T., Tanamoto, K. and Sawada, J. (2004) Propagation of a protease-resistant form of prion protein in long-term culture human glioblastoma cell line T98G. J. Gen. Virol., 85: 3449-3457.

Nishibori, N., Shimamoto, T., Horiuchi, H., Furusawa, S. and Matsuda, H. (2004) Expression vectors for chicken-human chimeric antibodies. Biologicals, 32:213-218.

Shigeta, A., Sato, M., Kawashima, T., Horiuchi, H., Matsuda, H. and Furusawa, S. (2004) Genomic organization of the chicken T-cell receptor beta chain D-J-C region. J. Vet. Med Sci., 66:1509-1515.
2003
Yasuda, M., Kajiwara, K., Ekino, E., Taura, Y., Hirota, Y., Horiuchi, H., Matsuda, H. and Furusawa, S. (2003) Immunobiology of chicken germinal center: I. Changes in surface Ig class expression in the chicken splenic germinal center after antigenic stimulation. Dev. Comp. Immunol., 27:156-166.

Ono, K., Kamihira, M., Kuge, Y., Matsumoto, H., Hotta, A., Itoh, T., Nishijima, K., Nakamura, N., Matsuda, H. and Iijima, S. (2003) Production of anti-prion scFv-Fc fusion proteins by recombinant animal cells. J. Biosci. Bioeng., 95:231-238.

Kajiwara, E., Shigeta, A., Horiuchi, H., Matsuda, H. and Furusawa, S. (2003) Development of Peyer's patch and cecal tonsil in gut-associated lymphoid tissues in the chicken embryo. J. Vet. Med. Sci., 65,607-614.

Kushima, K., Fujita, M., Shigeta, A., Horiuchi, H., Matsuda, H. and Furusawa, S. (2003) Effect of restraint stress on chicken peripheral blood NK cells. J. Vet. Med. Sci, 65: 995-1000.

松田治男、堀内浩幸、古澤修一、(2003) 遺伝子組み換え技術を活用した有用鶏開発の現状と将来、養鶏の友、9月号

Nakamura, N., Shimokawa, M., Miyamoto, K., Hojyo, S., Horiuchi, H., Furusawa, S. and Matsuda, H. (2003) Two expression vectors for the phage-displayed chicken monoclonal antibody. J. Immunol. Methods, 280: 157-164.

Nakamura, N., Miyamoto, K., Shimokawa, M., Nishida, N., Mohri, S., Kitamoto, T., Horiuchi, H., Furusawa, S. and matsuda, H. (2003) Generation of antibodies against prion protein by scrapie-infected cell immunization of PrP0/0 mice. Hybridomas and Hybridomics, 22: 263-226.

Yasuda, M., Kajiwara, K., Ekino, S., Taura, Y., Hirota, Y., Horiuchi, H., Matsuda, H. and Furusawa, S. (2003) Immunobiology of chicken germinal center: II Accumulation of apoptptic cells within the germinal center. Cell Tissue Research., 314:215-221.

Koda, T., Aosasa, M., Asaoka, H., Nakaba, H. and Matsuda, H. (2003) Application of tyramide signal amplification for detection of N-glycolylneuraminic acid in human hepatocellular carcinoma. Int. J. Clin. Oncol., 8:317-321.


2002
Kikuchi, Y., Kakeya, T., Yamazaki, T., Takekida, K., Nakamura, N., Matsuda, H., Takatori, K., Tanimura, A., Tanamoto, K. and Sawada, J. (2002) G1-dependent prion protein expression in human glioblastoma cell line T98G. Biol. Pharm. Bull., 25(6) 728-733

Horiuchi, H., Inoue, T., Furusawa, S. and Matsuda, H. (2002) Cloning and characterization of a chicken platelet-derived growth factor B-chain cDNA. Dev. Comp. Immunol., 26,73-83.

Uchiyama, S., Fujikawa, Y., Uematsu, K., Matsuda, H., Aida, S. and Iijima, N. (2002) Localization of group IB phospholipase A2 isoform in the gills of the red sea bream, Pagrus (Chrysophrys) major. Comp. Biochem. Physiol. Part B, 132,671-683.

堀内浩幸、古澤修一、松田治男 (2002) ニワトリサイトカイン探索とその応用、家畜栄養生理研究会報、46,137-149.


2001
Otsubo, Y., Chen, N., Kajiwara, E., Horiuchi, H., Matsuda, H. and Furusawa, S. (2001) Role of bursin on the development of B lymphocytes in chicken embryonic bursa of Fabricius. Dev. Comp. Immunol., 25:485-493.

Kawano, K., Furusawa, S., Matsuda, H., Takasa, M. and Nakamura, M. (2001) Expression of steroidogenic factor-1 in frog embryo and developing gonad. Gen. Comp. Endoc., 123:13-22.

Horiuchi, H., Inoue, T., Furusawa, S. and Matsuda, H. (2001) Cloning and expression analyses of three different forms of cDNA coding for chicken platelet-derived growth factor-A chain. Gene 272:181-190.

浅川英男, 松下 央, 李 康弘, 深井文雄, 松田治男, 窪田哲朗, 森 亘, (2001) 各種固形癌および白血病おけるGM3(NeuGc)に対する抗体, 医学の歩み, 198:479-480.

松田治男 (2001) ニワトリモノクローナル抗体の活用戦略、バイオサイエンスとインダストリー、59,763-764.

Furusawa, S., Kushima, K., Shigeta, A., Horiuchi, H. and Matsuda, H. (2001) CD3+CD4-CD8-cells present in chicken peripheral blood area regulated by aging and stress. Current Progress on Avian Immunology Research, p. 315-321, 2001

Nakamura, N., Horiuchi, H., Furusawa, S. and Matsuda, H. (2001) Construction of recombinant chicken monoclonal antibody using phage displayed system. Current Progress on Avian Immunology Research, p. 335-340, 2001


2000
Nakamura, N., Aoki, Y., Horiuchi, H., Furusawa, S., Yamanaka, H. I., Kitamoto, T. and Matsuda, H. (2000) Construction of recombinant monoclonal antibodies from a chicken hybridoma line secreting specific antibody. Cytotechnol., 31, 191-198.

Kitao, H., Arakawa, H., Kuma, K., Yamagishi, H., Nakamura, N., Furusawa, S., Matsuda, H., Yasuda, M., Ekino, S. and Shimizu, A. (2000) Class switch recombination of the chicken IgH chain genes: implications for the primordial switch region repeats. Int. Immunol., 12:959-968.

Kobayashi, T., Suzuki, A., Yokoyama, I., Abe, M., Hayashi, S., Nagasaka, T., Namii, Y., kato, T., Tokoro, T., Liu, D., nakano, A., Matsuda, H., Morozumi, K., Breimer, M. E., Rydberg, L., Groth, C. G., Tibell, A., Korsgren, O. and Takagi, H. (2000) Immunogenicity of Hanganutziu-Deicher antigens in pig-to-human xenotransplantation. Transplant. Proc., 32:874.

Kobayashi, T., Yokoyama, I., Suzuki, A., Abe, M., Hayashi, S., Matsuda, H., Morozumi, K., Breimer, M. E., Rydberg, L., Groth, C. G., Tibell, A., Korsgren, O., Takagi, H. and Nakao, A. (2000) Lack of antibody production against hanganutziu-Deicher (H-D) antigens with N-glycolylneuraminic acid in patients with porcine exposure history. Xenotransplant., 7:177-180.

1999
Morozumi, K., Kobayashi, T., Usami, T., Oikawa, T., Ohtsuka, Y., Kato, M., Takeuchi, O., Koyama, K., Matsuda, H., Yokoyama, I. and Takagi, H. (1999) Significance of the histochemical expression of Hanganutziu-Deicher (HD) antigens in pig, baboon and human tissues. Transplant. Proc., 31,942-944.

Matsuda, H., Mitsuda, H., Nakamura, N., Furusawa, S., Mohri, S. and Kitamoto, T. (1999) A chicken monoclonal antibody with specificity for the N-terminal of human prion protein. FEMS Immunol. and Med. Microbiol., 23, 189-194.

Fukushima, K., Murata, Y., Seto, T., Furusawa, S. and Matsuda, H. (1999) In vitro system for immunoglobulin class switching using BHK cells transfected with murine recombinant CD40 ligand. J. Vet. Med. Sci., 61, 615-619.


1998
古澤修一、堀内浩幸、松田治男(1998) 鶏ファブリキウス嚢の構造、鶏病研究会報、34,11-19.

Sasai, K., Lillehoj, H. S., Hemphill, A., Matsuda, H., Hanioka, Y., Fukata, T., Baba, E. and Arakawa, A. (1998) A chicken anti-conoid monoclonal antibody identifies an common epitope which is present on motile stages of Eimeria, Neospora and Toxoplasma. J. Parasitol., 84:654-656. 

Yasuda, M., Furusawa, S., Matsuda, H., Taura, Y., Yokomizo, Y. and Ekino, S. (1998) Development of maternal IgG-free chick obtained from surgically bursectomized hen. Comp. Immunol. Microbiol. Infect. Dis., 21:191-200.

Matsushita, K., Horiuchi, H., Furusawa, S., Horiuchi, M., Shinagawa, M. and Matsuda, H. (1998) Chicken monoclonal antibody against bovine prion protein peptides. J. Vet. Med. Sci., 60:777-779.

Tachi, Y., Kobayashi, T., Yokoyama, I., Hayashi, S., Negita, M., Namii, Y., Katayama, A., Nagasaka, T., Mei, G-L., Hayakawa, A., Matsuda, H., Muramatsu, T. and Takagi H. (1998) Variability of cytotoxicity to pig cultured cells and its determinant factor in human sera. Transplant. Proc., 30, 71-73.

Ekino, S., Yasuda, M., Arakawa, H., Yamagishi, H., Furusawa, S., Matsuda, H., Taura. Y.and Yokomizo. Y. (1998) Chicken follicular immunity: comparative study of the bursa of Fabricius and germinal center. In: The challanges of lower vertebrates to immunology, pp. 64-67, Kyoto.

Ogawa, M., Yamaguchi, T., Setiyone, A., Ho, T., Matsuda, H., Furusawa, S., Fukushi, H. and Hirai, K. (1998) Some characteristics of a cellular receptor for virulent infectious bursal disease virus by using flow cytometry. Arch. Virol., 143, 2327-2341.